Is CBD Better Than Advil for Pain?

by Msnbctv news staff

Written by Jen Keehn

Up to date September 21, 2021

Dr. Zora DeGrandpre

Medically Reviewed by Dr. Zora DeGrandpre

Are you in ache? Right here. Seize an Advil. Take it! Take it! Your ache will go away quickly. After which thanks, Advil!

However actually?

Are Advil or different types of ibuprofen (Motrin) actually worthy of your reward and thanks? What in regards to the unintended effects?

We’re going to introduce you to an all-natural various to NSAIDs resembling Advil/Ibuprofen. CBD vs Ibuprofen: Is one higher than the opposite? Let’s discover out.

What it’s best to find out about Advil

Advil, whose generic title ibuprofen, is a Non-Steroidal Anti-Inflammatory Drug or NSAID, and is likely one of the hottest painkillers. 

NSAIDs like Advil are simply accessible, inexpensive, and efficient in controlling ache.

However what if I advised you that Advil has unintended effects that you have to be cautious of?

It’s a comparatively lengthy record, however here’s a shortened model: upset abdomen, bloating, gassiness, constipation, indigestion, coronary heart palpitations, hypertension (hypertension), lack of urge for food, headache, dizziness, drowsiness, thirst, sweating, swollen ankles and lightheadedness. Lengthy-term use of Advil/Ibuprofen may cause ulcers, listening to loss, an elevated danger of coronary heart assaults and kidney and/or liver harm1

However might individuals assume they want their Advil to regulate ache and ignore all of the unintended effects they could have examine long-term Advil use.

Sadly, the unintended effects of Advil are actual.

The longer you utilize Advil/ibuprofen painkillers and the upper their dosage, the upper your danger for creating listening to loss, kidney illness, coronary heart issues, and gastrointestinal bleeding.

What it’s best to find out about CBD

CBD Oil Vs Advil/Ibuprofen

We all know that Advil/Ibuprofen have unintended effects—generally critical ones. What’s the security profile for CBD? 

Probably the most present overview of the adversarial results (AE) and poisonous results of CBD concluded that “In people receiving the drug for the therapy of epilepsies and psychiatric problems, the commonest AEs included tiredness, diarrhea, nausea, and hepatotoxicity. General, the incidence of those occurrences is low and, as compared with different medication employed for the therapy of those illnesses, CBD has a greater facet impact profile2.” The overview additionally acknowledged that CBD has been related to fetal toxicity, so at this level, it’s most secure that CBD shouldn’t be taken by pregnant girls, however that total, CBD is related to an appropriate security profile and must be additional investigated for drug interactions.

What medication may work together with CBD3? Drug interactions must do with the actions of liver enzymes and should end in both decreased or elevated actions of varied medication when used collectively. The most important issues are interactions with:

  • Buprenorphine
  • Leflunomide
  • Levomethadyl acetate
  • Lomitapide
  • Mipomersen
  • Pexidartinib
  • Propoxyphene
  • Sodium oxybate
  • Teriflunomide

Additionally, search for the “grapefruit warning” which signifies that individuals taking a selected treatment ought to keep away from consuming or ingesting grapefruit or grapefruit juice. 

For most individuals, the unintended effects of CBD are minimal and momentary, however it’s best to all the time discuss to your healthcare supplier and pharmacist earlier than including CBD (or every other product) to your routine.

However how efficient is CBD in lowering ache and irritation—in comparison with Advil/Ibuprofen or every other NSAID?

We don’t have direct comparisons between Advil/Ibuprofen and CBD for ache and irritation. However we do know that CBD is efficient in lowering ache underneath numerous circumstances resembling for arthritic ache, complications, continual ache and different painful situations4, 5. As talked about, we additionally know that CBD is sort of protected when used for these situations—whether or not in a topical type—as in lowering ache in arthritic joints—or as CBD oil or capsule for continual ache.

Importantly, CBD doesn’t have any intoxicating results and gained’t produce hallucinations, temper adjustments, psychological adjustments, drowsiness, and so forth. as a result of it’s a non-psychoactive compound and is, the truth is, neuroprotective6, 7

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Makes use of of Advil and CBD

Each Advil and CBD are used for ache and irritation.

However CBD has the flexibility to assist extra than simply these signs although.  CBD can also be an efficient antioxidant, so whereas it’s lowering ache and irritation, it’s additionally defending the wholesome cells in opposition to the harmful byproducts of metabolism like free radicals8. In different phrases, not solely is CBD an efficient device for ache aid, it additionally helps defend your physique from harm.

Dosing with CBD

The widely accepted strategy is to “Begin low and go gradual”. This implies to start out with as low a dose as doable—by taking, for instance ¼ of a dropperful of CBD tincture or reducing a CBD edible into quarters.  Then, give your self at the least 20 minutes to observe the consequences.  If there aren’t any noticeable results—eg. little or no ache aid, begin slowly growing the dose—by including, for instance, an extra ½ dropperful of CBD oil or ½ an edible. Monitor your response, giving the CBD at the least 20-Half-hour to unfold by way of your physique. As soon as you discover your greatest dose, you might be carried out!  In case you are utilizing topical CBD, the identical strategy can be utilized—utilizing a really small quantity to start out and slowly growing the quantity your rub into your aching joint. With CBD, you have got extra management together with your dosage. 

A standard beginning dose is 2.5 mg of CBD per day, slowly elevated to about 20 mg of CBD per day for a lot of.

May CBD be higher than Advil or Ibuprofen?

It’s clearly your selection whether or not to make use of Advil and different ibuprofen merchandise or to make use of CBD to your ache.  However studying by way of all of the analysis research reporting that CBD can profit even persistent, continual, and intractable ache and be understanding it has a superb security profile, what do you truthfully assume?

Tell us within the feedback part beneath.

I’ll depart you with yet one more thought to ponder:

In response to a Professor on the College of Oxford’s Division of Pharmacology, Dr. Leslie Iversen, in a guide he printed in 2000 entitled “The Science of Marijuana,” hashish is safer than aspirin.

As all the time, please communicate to your physician and pharmacist earlier than utilizing both CBD or Advil/Ibuprofen for any situation.


1Ibuprofen Aspect Results: Widespread, Extreme, Lengthy Time period. (2020, July 26). Retrieved January 07, 2021, from  

2Huestis, M. A., Solimini, R., Pichini, S., Pacifici, R., Carlier, J., & Busardò, F. P. (2019). Cannabidiol Adversarial Results and Toxicity. Present neuropharmacology17(10), 974–989.

3Brown, J., & Winterstein, A. (2019, July 08). Potential Adversarial Drug Occasions and Drug–Drug Interactions with Medical and Client Cannabidiol (CBD) Use. Retrieved January 07, 2021, from

4VanDolah, H. J., BA, Bauer, B. A., MD, & Mauck, Okay. F., MD. (2019, August 21). Clinicians’ Information to Cannabidiol and Hemp Oils. Retrieved January 07, 2021, from

5Argueta, D. A., Ventura, C. M., Kiven, S., Sagi, V., & Gupta, Okay. (2020). A Balanced Strategy for Cannabidiol Use in Power Ache. Frontiers in pharmacology11, 561.

6Iuvone T, Esposito G, Esposito R, Santamaria R, Di Rosa M, Izzo AA. Neuroprotective impact of cannabidiol, a non‐psychoactive element from Hashish sativa, on β‐amyloid‐induced toxicity in PC12 cells. Journal of neurochemistry. 2004 Feb;89(1):134-41. Retrieved January 07, 2021, from

7Costa B, Trovato AE, Comelli F, Giagnoni G, Colleoni M. The non-psychoactive hashish constituent cannabidiol is an orally efficient therapeutic agent in rat continual inflammatory and neuropathic ache. European journal of pharmacology. 2007 Feb 5;556(1-3):75-83. Retrieved January 07, 2021, from

8Hampson AJ, Grimaldi M, Axelrod J, Wink D. Cannabidiol and (−) Δ9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the Nationwide Academy of Sciences. 1998 Jul 7;95(14):8268-73. Retrieved January 07, 2021, from

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