In his 1978 tune “Bush Physician,” Peter Tosh espoused the well being advantages of marijuana by citing two illnesses that will strike some listeners as odd: glaucoma and bronchial asthma. However Tosh had his info straight. Glaucoma was really one of many first indications for which the U.S. authorities supplied canisters of marijuana cigarettes to a handful of sufferers starting within the late Seventies. And experiments across the similar time additionally confirmed that marijuana smoke can dilate and open up the airways – not like tobacco smoke, which has the other impact.
Have been he nonetheless alive immediately, Tosh would probably really feel each vindicated and amazed by the unimaginable vary of illnesses whose remedy with hashish and CBD has been scientifically supported in recent times. Many extra are presently being investigated – and nonetheless others are being probed, on the very least, for endocannabinoid system involvement.
As for Tosh, his 1976 anthem “Legalize It” additionally sang pot’s praises as a remedy for the flu, tuberculosis, and a mysterious (although rhyming) situation referred to as “numara thrombosis.” We might by no means unravel what he meant by that one, however listed here are three more moderen papers in field-specific medical journals on obscure or surprising therapeutic functions of hashish and cannabinoids.
CBD for oral ulcers
Researchers in China wished to know whether or not treating oral ulcers may be among the many many potential makes use of of CBD. To search out out, they examined a CBD-infused oral spray at three completely different concentrations (0, 1, and 10 mg/mL) on tongue ulcers in mice over the course of three days. Their outcomes, printed this month within the Journal of Dental Analysis,1 point out that not solely did the CBD-treated mice typically recuperate sooner than the management animals, however the high-dose CBD group tended to fare higher than the low-dose group.
The researchers additionally investigated the mechanisms behind this impact. They decided it to be largely attributable to immune response and inflammatory pathways mediated by direct activation of PPARy nuclear receptors, a predominant goal of CBD, and, to a lesser extent, partial activation of CB1 receptors. This work was funded partly by a China-based pharmaceutical firm.
PEA for gynecologic ache
Cannabinoids are well-known for his or her means to fight ache and irritation. So researchers within the Division of Gynecology and Obstetrics at Johns Hopkins College of Drugs (with a working towards OB/GYN as senior creator) performed a scientific evaluate of present research on the usage of hashish for gynecologic ache circumstances. These embrace persistent pelvic ache, reported to have an effect on one in 4 girls worldwide;2 dysmenorrhea; vulvodynia; endometriosis; interstitial cystitis (bladder ache syndrome); and gynecologic malignancy.
Sixteen research met inclusion standards for the evaluate, which was printed this month within the journal Obstetrics and Gynecology3 and lined within the February episode of the journal’s podcast. Two randomized managed trials and 6 potential cohort research evaluated the efficacy of medicines containing both palmitoylethanolamide (PEA, an endocannabinoid-like compound) or an inhibitor of fatty acid amide hydrolase (FAAH, an enzyme that degrades PEA and endocannabinoids), whereas eight cross-sectional research evaluated hashish use.
“Survey knowledge confirmed that the majority girls reported that hashish improved ache from quite a few gynecologic circumstances,” the authors write. “Cohort research and an RCT utilizing PEA-combination drugs reported ache discount.” Whereas promising, these findings include lots of the traditional caveats: “Interpretation of the research is proscribed resulting from various hashish formulations, supply strategies, and dosages that preclude a definitive assertion about hashish for gynecologic ache aid.”
Hashish for spinal issues
Additionally printed in Feb. 2022, a brand new paper within the journal Present Opinions in Musculoskeletal Drugs4 summarizes latest analysis surrounding the usage of hashish and cannabinoids in 4 “spinal dysfunction” contexts: persistent low again ache; spinal twine harm; earlier than and after surgical procedure; and normal orthopedic procedures. The narrative evaluate identifies key research and papers in every of those areas and gives an summary of their findings relative to numerous elements, together with ache, spasticity, surgical procedure restoration, and opioid use.
The lengthy and the in need of it: proof for hashish use in spinal issues continues to be restricted and of typically low high quality however comprises some promising nuggets.
“That is an attention-grabbing and burgeoning space of musculoskeletal analysis, as sufferers with backbone issues may be severely bothered with persistent ache with out many efficient ache remedy choices,” senior creator and Northwestern College orthopedic surgeon Srikanth Divi mentioned in an e-mail to Challenge CBD.
“Earlier than we are able to advocate it routinely for sufferers that bear surgical procedure, we have to know its organic results on backbone fusions and long-term issues. This is able to require strong potential research. For now, for sufferers that state they get good aid from CBD or THC merchandise that aren’t operative candidates, I feel it could be an efficient various remedy.”
Nate Seltenrich, an unbiased science journalist based mostly within the San Francisco Bay Space, covers a variety of topics together with environmental well being, neuroscience, and pharmacology.
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